A. Distance metrics (unweighted Unifrac, weighted Unifrac, Jensen-Shannon, Root Jensen-Shannon, Bray-Curtis) were scored with average silhouette width (SW), Calinski-Harabasz (CH), and prediction strength to identify the number of clusters with most support. Modest support for clustering into three groups was supported by SW and CH. B. (Top) Boxplots of genera selected as seed regions for co-occurrence networks. (Bottom) Co-occurrence networks show positive and negative correlations between different genera.