. Author manuscript; available in PMC: 2019 Jan 1.

Published in final edited form as: Med Clin North Am. 2017 Oct 21;102(1):65–85. doi: 10.1016/j.mcna.2017.08.007

Table 2.

Relative and Absolute Contraindications to Weight-Loss Medications in Older Adults

Generic Name	Absolute Contraindications	Side-Effects (>10%) & Major Risks in Older Adults
Locarserin	—	Renal insufficiency, Tramadol, Heart failure, Serotonin excess, hypoglycemia
Phentermine/Topiramate	Glaucoma, MAOI hyperthyroidism	Constipation headache, xerostomia
Phentermine	Glaucoma, Heart failure, CAD, Hyperthyroidism, Arrhythmias	Renal insufficiency, Reduced exercise tolerance
Orlistat	Malabsorption, cholestasis	Fecal urgency, Flatulence, Steatorrhea
Buproprion/naltrexone	HTN, Seizures, Hepatic impairment	More sensitive to CNS effects, Renal insufficiency, Headache, Constipation, N/V
Liraglutide	Angioedema, MEN-2, MTC	Constipation, Diarrhea, Hypoglycemia, Palpitations, N/V