Table 3.
Proven and Probably PFI after Pediatric Lung Transplantation
| ID | Demographics | Pre-Tx cultures (R=recipient; D=Donor) |
Early extended Prophylaxis |
Event Type | Time to event (event length) |
Organisms | Therapy |
|---|---|---|---|---|---|---|---|
|
| |||||||
| 1 | 16.3 y.o.; M; CF | R: Mold* | (no opportunity for prophylaxis) | Probable | 0 (20) | Mold* | Ampho (i); Vori |
|
|
|||||||
| 1 | Proven | 5 (15) | C. parapsilosis | Ampho (i); Vori | |||
|
| |||||||
| 2 | 18.2 y.o.; F; CF | R: A. flavus | Vori | Proven | 172 (11) | C. glabrata | Vori |
|
| |||||||
| 3 | 17.5 y.o.; F; CF | D: C. tropicalis | Ampho (i); Vori; Micafungin | Probable | 172 (188) | Candida Species | Ampho (i); Micafungin |
|
|
|||||||
| 3 | Probable | 727 (uk) | C. glabrata | Micafungin | |||
|
| |||||||
| 4 | 14.7 y.o.; F; CF | R: A. fumigatus | Ampho (i); Vori | Probable | 489 (55) | Penicillium | |
|
| |||||||
| 5 | 18.0 y.o.; F; Complex Congenital Heart Disease | Anidulafungin | Probable | 181(uk) | A. fumigatus | Vori | |
|
|
|||||||
| 5 | Probable | 380 (123) | Penicillium | Anidulafungin | |||
|
| |||||||
| 6 | 17.7 y.o.; M; CF | Vori; Anidulafungin | Probable | 64 (uk) | Penicillium | Vori | |
|
| |||||||
| 7 | 8.0 y.o.; F; IPF | Probable | 126 (95) | A. fumigatus | Ampho (i); Vori | ||
|
| |||||||
| 8 | 16.1 y.o.; F; CF | R: Yeast | Probable | 10 (69) | A. flavus | Fluconazole; Vori; Ampho (i & IV) | |
|
| |||||||
| 9 | 19.1 y.o.; F; PPHTN | Proven | 10 (59) | C. albicans | |||
|
| |||||||
| 10 | 17.0 y.o.; M; CF | R: C. albicans; R: Aspergillus species | Ampho (i); Vori | Probable | 40 (uk) | C. glabrata | Ampho (i) |
CF=Cystic Fibrosis; M=Male; F=Female; uk=Unknown end date of infection; Ampho=Amphotericin; Vori=voriconazole; (i)=Route-Inhaled; IV=Route-Intravenous;
*
= positive galactomannan blood immunoassay