Table 2. Genetic distributions of HVEM/LIGHT/BTLA/CD160 polymorphisms between the ABMR and stable group.
| Genotype | Chromosome | Position | Stable group (n=131) | ABMR group (n=69) | HWE for the stable group | |
|---|---|---|---|---|---|---|
| Χ2 | P value | |||||
| HVEM | ||||||
| rs4870 | Chr1 | 2488153 | 0.74 | 0.69 | ||
| AA | 38 | 24 | ||||
| AG | 70 | 34 | ||||
| GG | 23 | 11 | ||||
| rs2234158 | Chr1 | 2489200 | <0.01 | 0.99 | ||
| CC | 103 | 69 | ||||
| CT | 1 | 0 | ||||
| rs376994775 | Chr1 | 2489746 | <0.01 | 0.99 | ||
| CC | 130 | 69 | ||||
| CT | 1 | 0 | ||||
| rs754021885 | Chr1 | 2489961 | <0.01 | 0.99 | ||
| CC | 130 | 68 | ||||
| CT | 1 | 1 | ||||
| rs572222644 | Chr1 | 2491163 | <0.01 | 0.99 | ||
| CC | 131 | 68 | ||||
| CT | 0 | 1 | ||||
| rs2234161 | Chr1 | 2491205 | <0.01 | 0.99 | ||
| CC | 36 | 20 | ||||
| CT | 65 | 35 | ||||
| TT | 30 | 14 | ||||
| rs2234162 | Chr1 | 2491305 | <0.01 | 0.99 | ||
| CC | 130 | 69 | ||||
| CT | 1 | 0 | ||||
| rs2234163 | Chr1 | 2491306 | 0.23 | 0.89 | ||
| GG | 123 | 64 | ||||
| GA | 8 | 5 | ||||
| rs2234165 | Chr1 | 2492276 | 0.39 | 0.82 | ||
| GG | 120 | 63 | ||||
| GA | 11 | 6 | ||||
| rs575127151 | Chr1 | 2492935 | <0.01 | 0.99 | ||
| GG | 131 | 68 | ||||
| GA | 0 | 1 | ||||
| rs375010878 | Chr1 | 2493087 | <0.01 | 0.99 | ||
| CC | 130 | 68 | ||||
| CT | 1 | 1 | ||||
| rs2234167 | Chr1 | 2494330 | 0.16 | 0.92 | ||
| GG | 123 | 66 | ||||
| GA | 8 | 3 | ||||
| rs8725 | Chr1 | 2494785 | 0.01 | 0.99 | ||
| GG | 37 | 19 | ||||
| GA | 64 | 35 | ||||
| AA | 30 | 15 | ||||
| rs376495994 | Chr1 | 2496492 | <0.01 | 0.99 | ||
| GG | 131 | 68 | ||||
| GA | 0 | 1 | ||||
| rs186536172 | Chr1 | 2496521 | <0.01 | 0.99 | ||
| CC | 130 | 68 | ||||
| CT | 1 | 1 | ||||
| rs7544646 | Chr1 | 2496649 | 0.38 | 0.83 | ||
| CC | 47 | 19 | ||||
| CG | 59 | 35 | ||||
| GG | 25 | 15 | ||||
| rs7515633 | Chr1 | 2496653 | 0.18 | 0.91 | ||
| AA | 43 | 19 | ||||
| AG | 61 | 35 | ||||
| GG | 27 | 15 | ||||
| LIGHT | ||||||
| rs344560 | Chr19 | 6665020 | 0.55 | 0.76 | ||
| TC | 13 | 7 | ||||
| CC | 118 | 62 | ||||
| rs772372888 | Chr19 | 6665098 | <0.01 | 0.99 | ||
| CC | 130 | 69 | ||||
| CT | 1 | 0 | ||||
| rs61761328 | Chr19 | 6665099 | 0.02 | 0.99 | ||
| GG | 127 | 69 | ||||
| GA | 4 | 0 | ||||
| rs183886666 | Chr19 | 6665336 | <0.01 | 0.99 | ||
| GG | 131 | 68 | ||||
| GA | 0 | 1 | ||||
| rs8101047 | Chr19 | 6665481 | 1.24 | 0.54 | ||
| AA | 4 | 0 | ||||
| AG | 38 | 25 | ||||
| GG | 89 | 44 | ||||
| rs542346038 | Chr19 | 6667076 | <0.01 | 0.99 | ||
| GG | 130 | 69 | ||||
| GA | 1 | 0 | ||||
| rs2291668 | Chr19 | 6669934 | 4.37 | 0.11 | ||
| GG | 63 | 26 | ||||
| GA | 57 | 38 | ||||
| AA | 11 | 5 | ||||
| rs2291667 | Chr19 | 6669986 | 0.05 | 0.98 | ||
| GG | 128 | 66 | ||||
| GA | 3 | 3 | ||||
| rs748673655 | Chr19 | 6669992 | <0.01 | 0.99 | ||
| CC | 130 | 69 | ||||
| CT | 1 | 0 | ||||
| rs344558 | Chr19 | 6670253 | 0.04 | 0.98 | ||
| AA | 114 | 56 | ||||
| AC | 17 | 12 | ||||
| CC | 0 | 1 | ||||
| rs563748272 | Chr19 | 6677752 | <0.01 | 0.99 | ||
| GG | 130 | 69 | ||||
| GT | 1 | 0 | ||||
| BTLA | ||||||
| rs2971205 | Chr3 | 112184772 | <0.01 | 0.99 | ||
| AA | 130 | 69 | ||||
| AG | 1 | 0 | ||||
| rs2171513 | Chr3 | 112184927 | 3.07 | 0.22 | ||
| AA | 15 | 3 | ||||
| AG | 42 | 25 | ||||
| GG | 74 | 41 | ||||
| rs770019001 | Chr3 | 112184932 | <0.01 | 0.99 | ||
| CC | 130 | 69 | ||||
| CG | 1 | 0 | ||||
| rs9288952 | Chr3 | 112185025 | 3.87 | 0.14 | ||
| GG | 24 | 5 | ||||
| GA | 48 | 29 | ||||
| AA | 59 | 35 | ||||
| rs76844316 | Chr3 | 112188609 | 0.02 | 0.99 | ||
| TT | 110 | 61 | ||||
| TG | 20 | 8 | ||||
| GG | 1 | 0 | ||||
| rs16859629 | Chr3 | 112190380 | <0.01 | 0.99 | ||
| TT | 130 | 69 | ||||
| TC | 1 | 0 | ||||
| rs9851198 | Chr3 | 117448419 | <0.01 | 0.99 | ||
| GG | 131 | 68 | ||||
| AA | 0 | 1 | ||||
| CD160 | ||||||
| rs2231375 | Chr1 | 145696694 | 0.67 | 0.71 | ||
| GG | 96 | 55 | ||||
| GA | 31 | 13 | ||||
| AA | 4 | 1 | ||||
| rs3766526 | Chr1 | 145698637 | <0.01 | 0.99 | ||
| GG | 131 | 68 | ||||
| GA | 0 | 1 | ||||
| rs368476773 | Chr1 | 145698914 | <0.01 | 0.99 | ||
| CC | 131 | 68 | ||||
| CT | 0 | 1 | ||||
| rs193141418 | Chr1 | 145698935 | 0.06 | 0.97 | ||
| CC | 125 | 68 | ||||
| CT | 6 | 1 | ||||
| rs587741068 | Chr1 | 145703913 | <0.01 | 0.99 | ||
| AA | 130 | 69 | ||||
| AG | 1 | 0 | ||||
| rs587727931 | Chr1 | 145704474 | <0.01 | 0.99 | ||
| GG | 130 | 69 | ||||
| GA | 1 | 0 | ||||
Abbreviations: ABMR, antibody-mediated rejection; HVEM, herpes virus entry mediator; LIGHT, homologous to lymphotoxin (lymphotoxin-like), exhibits inducible expression and competes with HSV glycoprotein D for binding to herpesvirus entry mediator, a receptor expressed on T lymphocytes; BTLA, B and T lymphocyte attenuator; CD, cluster of differentiation; NA, not available; HWE, hardy-weinberg equilibrium.