Table 4a. A comparison between the baseline characteristics of the RAGE rs2070600 genotypes and alleles in the IS patient and control groups.
| Characteristics | IS patient group | Control group | PGavalue | PAavalue | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotype n (%) | Allele n (%) | Genotype n (%) | Allele n (%) | |||||||||
| CC | CT | TT | C | T | CC | CT | TT | C | T | |||
| Age | ||||||||||||
| ≥70 years | 327(63.2) | 160(30.9) | 30(5.8) | 814(78.7) | 220(21.3) | 270(65.5) | 124(30.1) | 18(4.4) | 664(80.6) | 160(19.4) | 0.562 | 0.370 |
| <70 years | 328(63.4) | 166(32.1) | 23(4.4) | 822(79.5) | 212(20.5) | 400(66.3) | 196(32.5) | 7(1.2) | 996(82.6) | 210(17.4) | 0.012 | 0.146 |
| Gender | ||||||||||||
| Male | 437(63.5) | 219(31.8) | 32(4.7) | 1093(79.4) | 283(20.6) | 405(60.8) | 246(36.9) | 15(2.3) | 1056(79.3) | 276(20.7) | 0.027 | 0.921 |
| Female | 218(63.0) | 107(30.9) | 21(6.1) | 543(78.5) | 149(21.5) | 265(75.9) | 74(21.2) | 10(2.9) | 604(86.5) | 94(13.5) | 0.008 | 0.001 |
| Diabetes | ||||||||||||
| Yes | 175(65.8) | 77(28.9) | 14(5.3) | 427(80.3) | 105(19.7) | 69(69.0) | 29(29.0) | 2(2.0) | 167(83.5) | 33(16.5) | 0.562 | 0.370 |
| No | 480(62.5) | 249(32.4) | 39(5.1) | 1209(78.7) | 327(21.3) | 601(65.7) | 291(31.8) | 23(2.5) | 1493(81.6) | 337(18.4) | 0.027 | 0.146 |
| Hypertension | ||||||||||||
| Yes | 422(63.7) | 208(31.4) | 33(5.0) | 1052(79.3) | 274(20.7) | 167(69.6) | 65(27.1) | 8(3.3) | 399(83.1) | 81(16.9) | 0.287 | 0.146 |
| No | 233(62.8) | 118(31.8) | 20(5.4) | 584(78.7) | 158(21.3) | 503(64.9) | 255(32.9) | 17(2.2) | 1261(81.4) | 289(18.6) | 0.027 | 0.214 |
PG: P value of the difference in alleles between the case and control groups; PA: P value of the difference in genotype between the case and control groups
a adjusted for age, gender, smoking, hypertension, diabetes mellitus and hyperlipidaemia.
b P < 0.05 is indicated in bold font.