Table 4b. A comparison between the baseline characteristics of the HMGB1 rs2249825 genotypes and alleles in the IS patient and control groups.
| Characteristics | IS patient group | Control group | PGavalue | PAavalue | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotype n (%) | Allele n (%) | Genotype n (%) | Allele n (%) | |||||||||
| CC | CG | GG | C | G | CC | CG | GG | C | G | |||
| Age | ||||||||||||
| ≥70 years | 367(71.0) | 144(27.9) | 6(1.2) | 878(84.9) | 156(15.1) | 272(66.0) | 124(30.1) | 16(3.9) | 668(81.1) | 156(18.9) | 0.060 | 0.104 |
| <70 years | 369(71.4) | 139(26.9) | 9(1.7) | 877(84.8) | 157(15.2) | 417(69.2) | 170(28.2) | 16(2.7) | 1004(83.8) | 202(16.7) | 0.568 | 0.402 |
| Gender | ||||||||||||
| Male | 496(72.1) | 181(26.3) | 11(1.6) | 1173(85.2) | 203(14.8) | 451(67.7) | 196(29.4) | 19(2.9) | 1098(82.3) | 234(17.7) | 0.168 | 0.104 |
| Female | 240(69.4) | 102(29.5) | 4(1.2) | 582(84.1) | 110(15.9) | 238(68.2) | 98(28.1) | 13(3.7) | 574(82.2) | 124(17.8) | 0.168 | 0.402 |
| Diabetes | ||||||||||||
| Yes | 180(67.7) | 83(31.2) | 3(1.1) | 443(83.3) | 89(16.7) | 70(70.0) | 26(26.0) | 4(4.0) | 166(83.0) | 34(17.0) | 0.669 | 0.930 |
| No | 556(72.4) | 200(26.0) | 12(1.6) | 1312(80.2) | 224(19.8) | 619(67.7) | 268(29.3) | 28(3.1) | 1506(82.3) | 324(17.7) | 0.085 | 0.228 |
| Hypertension | ||||||||||||
| Yes | 468(70.6) | 188(28.4) | 7(1.1) | 1124(84.8) | 202(15.2) | 154(64.2) | 76(31.7) | 10(4.2) | 384(80.0) | 96(20.0) | 0.040 | 0.104 |
| No | 268(72.2) | 95(25.6) | 8(2.2) | 631(85.0) | 111(15.0) | 535(69.0) | 218(28.1) | 22(2.8) | 1288(83.1) | 262(16.9) | 0.568 | 0.381 |
PG: P value of the difference in alleles between the case and control groups; PA: P value of the difference in genotype between the case and control groups
a adjusted for age, gender, smoking, hypertension, diabetes mellitus and hyperlipidaemia.
b P < 0.05 is indicated in bold font.