Table 5. The relationship between RAGE and HMGB1 genotypes and IS stratified by CISS classification in IS patients.
| RAGE rs2070600 | HMGB1 rs2249825 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotype | P value | Allele | P value | Genotype | P value | Allele | P value | |||||||
| CC | CT | TT | C | T | CC | CG | GG | C | G | |||||
| Controls | 670 | 320 | 25 | 1660 | 370 | 689 | 295 | 31 | 1673 | 357 | ||||
| (66.0) | (31.5) | (2.5) | (81.8) | (18.2) | (67.9) | (29.1) | (3.1) | (82.4) | (17.6) | |||||
| Cases | ||||||||||||||
| LAA (n=653) | 407 | 212 | 34 | 0.036 | 1026 | 280 | 0.088 | 460 | 182 | 11 | 0.279 | 1102 | 204 | 0.184 |
| (62.3) | (32.5) | (5.2) | (78.6) | (21.4) | (70.4) | (27.9) | (1.7) | (84.4) | (15.6) | |||||
| PAD (n=262) | 173 | 79 | 10 | 0.468 | 425 | 99 | 0.839 | 190 | 68 | 4 | 0.279 | 448 | 76 | 0.184 |
| (66.0) | (30.2) | (3.8) | (81.1) | (18.9) | (72.5) | (26.0) | (1.5) | (85.5) | (14.5 | |||||
| CS (n=46) | 33 | 10 | 3 | 0.468 | 76 | 16 | 0.839 | 38 | 8 | 0 | 0.279 | 38 | 8 | 0.108 |
| (71.7) | (21.7) | (6.5) | (82.6) | (17.4) | (82.6) | (17.4) | (0.0) | (82.6) | (17.4) | |||||
| UE (n=70) | 40 | 25 | 5 | 0.262 | 105 | 35 | 0.839 | 46 | 24 | 0 | 0.708 | 116 | 24 | 0.894 |
| (57.1) | (35.7) | (7.1) | (75.0) | (25.0) | (65.7) | (34.3) | (0.0) | (82.9) | (17.1) | |||||
LAA: Large-artery atherosclerosis; PAD: Penetrating artery disease; CS: Cardioembolic Stroke; UE: Undetermined aetiology.