Table 3. Genotype frequencies of CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5, SULT1A1, SULT2A1, and UGT2B7 genes.
| Gene | Genotype | Predicted phenotype | n | % |
|---|---|---|---|---|
| CYP2B6 | *1/*1 | NF/NF | 34 | 54.8 |
| *1/*2B | NF/NF | 2 | 3.2 | |
| *1/*4 | NF/IOF | 7 | 11.3 | |
| *1/*5 | NF/NF | 1 | 1.6 | |
| *1/*6 | NF/DOF | 12 | 19.4 | |
| *1/*7 | NF/NF | 2 | 3.2 | |
| *1/*22 | NF/IOF | 1 | 1.6 | |
| *2B/*6 | NF/DOF | 2 | 3.2 | |
| *6/*6 | DOF/DOF | 1 | 1.6 | |
| CYP2C9 | *1/*1 | NF/NF | 64 | 88.9 |
| *1/*3 | NF/DOF | 6 | 8.3 | |
| *1/*7 | NF/NF | 2 | 2.8 | |
| CYP2C19 | *1/*1 | NF/NF | 25 | 35.7 |
| *1/*2 | NF/LOF | 29 | 41.4 | |
| *1/*3 | NF/LOF | 3 | 4.3 | |
| *1/*17 | NF/IOF | 4 | 5.7 | |
| *2/*2 | LOF/LOF | 4 | 5.7 | |
| *2/*3 | LOF/LOF | 3 | 4.3 | |
| *2/*17 | LOF/IOF | 1 | 1.4 | |
| *3/*3 | LOF/LOF | 1 | 1.4 | |
| CYP2D6 | *1/*1 | NF/NF (2)a | 12 | 15.0 |
| *1/*2 | NF/NF (2) | 7 | 8.8 | |
| *1/*5 | NF/LOF (1) | 4 | 5.0 | |
| *1/*10 | NF/DOF (1.5) | 22 | 27.5 | |
| *1/*41 | NF/DOF (1.5) | 3 | 3.8 | |
| *2/*10 | NF/DOF (1.5) | 8 | 10.0 | |
| *5/*10 | LOF/DOF (0.5) | 3 | 3.8 | |
| *6/*10 | LOF/DOF (0.5) | 1 | 1.3 | |
| *10/*10 | DOF/DOF (1) | 14 | 17.5 | |
| *10/*10xN | DOF/DOF, xN (1.5) | 1 | 1.3 | |
| *10/*39 | DOF/NF (1.5) | 3 | 3.8 | |
| *10/*41 | DOF/DOF (1) | 2 | 2.5 | |
| CYP3A4 | *1/*1 | Wt/Wt | 78 | 97.5 |
| *1/*5 | Wt/Vtb | 1 | 1.3 | |
| *1/*18 | Wt/Vt | 1 | 1.3 | |
| CYP3A5 | *1/*1 | NF/NF | 5 | 3.4 |
| *1/*3 | NF/DOF | 27 | 18.2 | |
| *3/*3 | DOF/DOF | 41 | 27.7 | |
| *3/*5 | DOF/DOF | 1 | 0.7 | |
| SULT1A1 | *1/*1 | Wt/Wt | 67 | 84.8 |
| *1/*2 | Wt/Vt | 12 | 15.2 | |
| SULT2A1 | *1/*1 | Wt/Wt | 80 | 100.0 |
| UGT2B7 | *1/*1 | Wt/Wt | 28 | 40.6 |
| *1/*2 | Wt/Vt | 27 | 39.1 | |
| *1/*3 | Wt/Vt | 8 | 11.6 | |
| *2/*3 | Vt/Vt | 5 | 7.2 | |
| *3/*3 | Vt/Vt | 1 | 1.4 |
DOF, decrease of function; IOF, increase of function; LOF, loss of function; NF, normal function; Vt, variant; Wt, wild type.
aActivity scores of CYP2D6 gene in parentheses.
bFor genes whose phenotype is not well predicted by the genotype, the presence or absence of the variant allele is presented.