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. 2017 Nov 1;8(59):100358–100370. doi: 10.18632/oncotarget.22229

Figure 1. KLF2 is downregulated in human GC and its expression level is correlated with patients’ survival.

Figure 1

(A) KLF2 expression was examined by using The Cancer Genome Atlas (TCGA) database. Average expression level of KLF2 was lower in gastric tumor specimens (n = 249, 5.588±0.06843, SEM) compared with normal samples (n = 33, 6.598±0.2504, SEM). *** P < 0.001. (B) Western blot analysis of KLF2 protein expression level in five paired human gastric cancer samples and adjacent normal tissues. The level of KLF2 protein expression was decreased in tumor tissue when compared with that in normal tissue. C indicates cancer tissue; N indicates adjacent normal tissue. (C) IHC staining of KLF2 in human gastric tumor. Left, KLF2 strong expression. Right, KLF2 weak expression. (D) Kaplan-Meier analysis of survival in 80 patients with gastric cancers. The survival for patients with strong KLF2 expression was significantly longer than that for the patients with weak KLF2 expression. P = 0.0077.