Figure 6. Effects of Sirtinol on H₂S-meliorated the function of cognition in CRS-treated rats.

Rats were cotreated with NaHS (100μmol/kg/d, i.p.) and CRS (4h) for 4 w and injected with Sirtinol ((10 nmol/d ×1w, i.c.v.) at the last week simultaneously. The rats were tested in the Y-maze test (A-B), the novel object recognition test (C-D), and the Morris Water Maze (E-K). Values are the mean ± S.E.M. (n=8-10). (A-B), the total arm entries (A) and the alternation performance (B) were recorded; (C-D), the discrimination index (C) and the total object exploration time of rats (D) in test period was recorded. (E-K), the swimming tracks of rats searching for the underwater platform at the 1st and 5th training days (E) and the latency traveled to find the platform during five days (F) in the acquisition phase was recorded; the number of times that the rats crossed the platform (H) and the percentage of time in target quadrant (I) in probe trial were recorded; the latency to reach the platform (J) and the average speed of rats (K) in the visible platform test were recorded. ^*P < 0.05, ^**P < 0.01, vs control group; ^#P < 0.05, ^##P < 0.01, vs CRS-treated alone group; ^&P < 0.05, ^&&P < 0.01, vs cotreated with CRS and NaHS (100 μmol/kg/d, i.p.) group.