Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Nov 1;8(59):100421–100432. doi: 10.18632/oncotarget.22244

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © 2017 Kosovec et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PMC Copyright notice

(A) qRT-PCR pre versus post treatment pathway analysis. Pre-treatment biopsy samples were compared with harvested samples post-abemaciclib administration. Paired analysis demonstrated downregulation of CDK4 (p=0.057), CDK6 (p=0.017), Cyclin D (p<0.01), Rb1 (p<0.01), and E2F1 (p=0.025). (B) qRT-PCR placebo versus abemaciclib pathway analysis. Endpoint placebo and abemaciclib treated samples were compared. Independent analysis demonstrated downregulation of CDK4 (p=0.016), CDK6 (p=0.064), Cyclin D (p<0.01), Rb1 (p=0.56), and E2F1 (p<0.01).