Table 1. (A) Abemaciclib complications and mortality. Of the 32 animals receiving treatment, 41% displayed general morbidity, 81% had at least one episode of diarrhea, and 94% revealed peritonitis upon necropsy. Of the animals with peritonitis, 28% were severe. 6 animals were either found dead (n=2) or euthanized (n=4) prior to the endpoint of the study due to severe health complications. (B) Placebo complications and mortality. Out of 25 animals, 4% showed signs of general morbidity, and 12% demonstrated mild peritonitis. All animals survived until the endpoint of the study.

ABEMACICLIB			PLACEBO
Complication	# of Animals (n = 32)	Additional Comments	Complication	# of Animals (n = 25)	Additional Comments
General Morbidity	13 (41%)		General Morbidity	1 (4%)
Diarrhea	26 (81%)	Mean = 3.89 days; Range = 1-10 days	Diarrhea	1 (4%)
Peritonitis	30 (94%)	Severe = 8 (28%); Mild = 22 (72%)	Peritonitis	3 (12%)	Mild = 3 (100%)
Penile Prolapse	2 (6%)		Penile Prolapse	0 (0%)
Respiratory Infection	2 (6%)		Respiratory Infection	0 (0%)
Found Dead	2 (6%)	Severe Peritonitis = 1 (50%)	Found Dead	0 (0%)
Euthanized Prior to Endpoint	4 (13%)	Severe Peritonitis = 1 (25%) Large Tumor = 1 (25%) General Morbidity = 2 (50%)	Euthanized Prior to Endpoint	0 (0%)
Endpoint	26 (81%)		Endpoint	25 (100%)