Table 9. Subgroup analysis for recurrence-free survival.
| No. of included articles | No. of cases | Pooled HR (95% CI) | Chi2 (p value) | I2 | Ph* | |
|---|---|---|---|---|---|---|
| Publication year | 0.1633 | |||||
| 1997–2009 | 16 | 1,816 | 2.05 (1.52–2.76) | 92.96 (< 0.00001) | 84% | |
| 2010–2015 | 18 | 2,765 | 1.58 (1.26–1.96) | 37.18 (0.003) | 54% | |
| Region | 0.7686 | |||||
| Asia | 16 | 2,167 | 1.66 (1.29–2.13) | 33.06 (0.005) | 55% | |
| Europe | 14 | 1,825 | 1.91 (1.41–2.58) | 76.87 (< 0.00001) | 83% | |
| America | 4 | 589 | 1.81 (1.04–3.15) | 9.93 (0.02) | 70% | |
| No. of patients | 0.3895 | |||||
| < 100 | 18 | 1,189 | 1.95 (1.44–2.65) | 69.11 (< 0.00001) | 75% | |
| ≥ 100 | 16 | 3,392 | 1.66 (1.36–2.03) | 37.44 (0.001) | 60% | |
| HR estimation | 0.5542 | |||||
| Univariate | 9 | 763 | 1.99 (1.30–3.05) | 29.03 (0.0003) | 72% | |
| Multivariate | 25 | 3,818 | 1.72 (1.40–2.12) | 111.81 (< 0.00001) | 79% | |
| Analysis results | < 0.0001 | |||||
| Not significant | 16 | 2,091 | 1.22 (1.05–1.43) | 22.48 (0.10) | 33% | |
| Significant | 18 | 2,490 | 2.28 (1.93–2.70) | 22.27 (0.17) | 24% |
HR: hazard ratio, CI: confidence interval.
Ph* for heterogeneity between subgroups with meta-regression analysis.