Figure 2. Forest plot for median survival time of MPM patients with or without HITHOC.
A random effect model was used due to non-significant heterogeneity of publications (I2 = 70.76, P = 0.002). Effect size was assessed by Hedges’s g and 95% CI, and the median overall survival (OS) or disease free survival (DFS) time was in favors HITHOC (Hedges’s g = 0.384 ± 0.105; 95% CI: 0.178∼0.591, P < 0.001). Isilk #1: patients treated with HITHOC following surgical intervention; Isilk #2: patients treated with talc pleurodesis followed by systemic treatment; Isilk #3: patients treated with pleurectomy/decortication followed by systemic treatment.