Table 1. Summary of the data extraction for systematic review.
| Author’s Name | Year | Country | Treatment | Drugs | Case of MPM | MST (m) | RFI (m) | OSR | Morbity | Reference |
|---|---|---|---|---|---|---|---|---|---|---|
| Rusch | 1994 | USA | P/D + HITHOC | CDDP | 28 | 17 | 1 yr: 68%; 2 yr: 40% | 6 | ||
| Yellin | 2001 | Israel | EPP + HITHOC | CDDP | 7 | 1 yr: 57% | 28 | |||
| de Bree | 2002 | Nethelands | CRS + HITHOC | 11 | 7 m: 82% | 47% | 14 | |||
| Monneuse | 2003 | France | Surgery + HITHOC | CDDP | 17 | T1 & T2: 41.3 | 1 yr: 74% | 29 | ||
| Mitomycin C | T3&T4: 4.5 | 5 yr: 27% | ||||||||
| van Ruth | 2003 | Nethelands | Doxorubicin | 24 | Pharmakinetics | 19 | ||||
| CDDP | ||||||||||
| van Ruth | 2003 | Nethelands | CRS + HITHOC | CDDP | 22 | 11 | 1 yr: 42% | 18 | ||
| Doxorubicin | ||||||||||
| Richards | 2006 | USA | Low dose: CDDP | 9 | 6 | 4 | 9∼32% | 20 | ||
| High dose: CDDP | 35 | 18 | 9 | |||||||
| Xia | 2006 | Japan | RT + HITHOC | CDDP/CBDCA | 11 | 27.1 | 24 | |||
| Lang-Lazdunski | 2011 | UK | P/D + HITHOC | CDDP | 36 | 24 | 1 yr: 91.7% | 3.9∼13.9% | 22 | |
| Pemetrexed | 2 yr: 61% | |||||||||
| Sugarbaker | 2012 | USA | P/D+HITHOC | Mitomycin C | 25 | Pharmakinetics | 21 | |||
| Doxorubicin | 4 | |||||||||
| Ried | 2013 | Germany | P/D + HITHOC | CDDP | 8 | 18 | 22 m: 50% | 27 | ||
| Ried | 2013 | Germany | P/D + HITHOC | CDDP | 10 | Pharmakinetics | 26 | |||
| Ishibashi | 2015 | Japan | P/D + HITHOC | CDDP | 4 | 23∼41 | 2 yr DFS: 75% | 25 | ||
| EPP + HITHOC | CDDP | 10 | 12.1 | 2 yr DFS: 27% | ||||||
| Lang-Lazdunski | 2015 | UK | P/D + RT + HITHOC | CDDP | 102 | 32 | 5 yr: 23.1% | 29.40% | 23 | |
| Migliore | 2015 | Italy | Debulking + HITHOC | CDDP | 6 | 13.6 | 30 | |||
| Migliore | 2015 | Italy | P/D + HITHOC | CDDP | 6 | 21.5 | 16.60% | 31 | ||
CDDP:cisplatin; CBDCA: carboplatinum;DFS: disease free survival; EPP: extrapleural pneumonectomy; HITHOC: hyperthermic intrathoracic chemotherapy; MPM: malignant pleural mesothelioma; MST: median survival time; OSR: overall survival rate; P/D: pleurectomy/decortication; RFI: recurrence free interval; RT: radiotherapy