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. 2017 Aug 24;8(59):99649–99665. doi: 10.18632/oncotarget.20587

Figure 10. Effect of silibinin on cartilage matrix degradation in mice OA models.

Figure 10

Mice were randomly divided into three groups: sham control group, OA group and silibinin group. Sham control group underwent sham operation, OA group and silibinin group were subjected to surgery for establishing OA models. After surgery, silibinin group received a gavage of silibinin (200 mg/kg) daily while OA group received a gavage of vehicle (0.5%CMC-Na) for 8 weeks. Immunohistochemistry of collagen-II, aggrecan, MMP-13 and ADAMTS-5 were assessed to the effect of silibinin on cartilage matrix degradation in mice OA models. Quantifcation of collagen-II, aggrecan, MMP-13 and ADAMTS-5-positive cells in cartilage samples (A-D). The values are mean ± SD. #p<0.05 compared with sham control group, *p <0.05 and **p< 0.01 compared with OA group. n = 10 for each group. Representative histologic images are shown.