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. 2017 Aug 24;8(59):99649–99665. doi: 10.18632/oncotarget.20587

Figure 2. Effect of silibinin on IL-1β-induced NO, PGE2, TNF-α and IL-6 production in human OA chondrocytes.

Figure 2

Human OA chondrocytes were pretreated for 2 h with various concentrations of silibinin (1, 10, 50 μM) and then stimulated or not stimulated with IL-1β (10 ng/ml) for 24 h. The nitrite levels in the culture medium were assessed by Griess reaction (B). The levels of PGE2, TNF-α and IL-6 were determined using ELISA (A,C,D). The values are mean ± SD. #p < 0.05 compared with control group, *p < 0.05, **p< 0.01 compared with IL-1β group. n=6.