Table 5a. Overall Survival Results for Non-Muscle Invasive Bladder Cancer.
| Univariate Analyses1 | Multivariate Analyses1 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | Median2 | HR3 | LCL | UCL | p4 | n | Median2 | HR3 | LCL | UCL | p4 | |
| Age (years) | ||||||||||||
| ≤ 65 | 183 | 16.7 | 1.00 | 181 | 15.4 | 1.00 | ||||||
| > 65 | 317 | 7.4 | 2.59 | 1.93 | 3.48 | <.0001 | 317 | 7.5 | 2.41 | 1.78 | 3.26 | <.0001 |
| Gender | ||||||||||||
| Female | 95 | 10.8 | 1.00 | 95 | 10.2 | 1.00 | ||||||
| Male | 405 | 9.6 | 1.14 | 0.82 | 1.58 | .44 | 403 | 9.7 | 1.07 | 0.77 | 1.49 | .68 |
| Tumor Grade | ||||||||||||
| Low | 219 | 14.2 | 1.00 | 219 | 14.0 | 1.00 | ||||||
| High | 279 | 7.2 | 2.10 | 1.62 | 2.73 | <.0001 | 279 | 7.4 | 2.11 | 1.43 | 3.12 | .0002 |
| Tumor Stage | ||||||||||||
| Ta or Tis | 253 | 12.4 | 1.00 | 252 | 9.3 | 1.00 | ||||||
| T1 | 247 | 7.7 | 1.67 | 1.30 | 2.15 | .0001 | 246 | 10.3 | 0.88 | 0.61 | 1.27 | .50 |
| Lymph Nodes | ||||||||||||
| N0 or NX | 487 | 10.2 | 1.00 | 486 | 10.0 | 1.00 | ||||||
| N1 | 13 | 2.7 | 4.03 | 2.19 | 7.41 | <.0001 | 12 | 4.3 | 2.66 | 1.39 | 5.08 | .003 |
| ANG | ||||||||||||
| 0-2 | 408 | 9.6 | 1.00 | 408 | 9.5 | 1.00 | ||||||
| 3-4 | 29 | 12.6 | 0.75 | 0.42 | 1.35 | .34 | 28 | 12.8 | 0.71 | 0.39 | 1.31 | .28 |
| MMP-2 | ||||||||||||
| 0-2 | 175 | 12.4 | 1.00 | 173 | 11.9 | 1.00 | ||||||
| 3-4 | 281 | 9.1 | 1.40 | 1.06 | 1.84 | .02 | 281 | 9.1 | 1.37 | 1.04 | 1.81 | .03 |
| 5-6 | 2 | 6.6 | 1.95 | 1.12 | 3.37 | 2 | 7.0 | 1.87 | 1.08 | 3.26 | ||
| p53 | ||||||||||||
| 0-2 | 284 | 10.4 | 1.00 | 284 | 9.5 | 1.00 | ||||||
| 3-4 | 173 | 9.7 | 1.08 | 0.87 | 1.35 | .49 | 173 | 10.6 | 0.89 | 0.70 | 1.13 | .34 |
| 5-6 | 24 | 9.1 | 1.17 | 0.75 | 1.82 | 24 | 11.7 | 0.80 | 0.49 | 1.28 | ||
| Rb | ||||||||||||
| 0-2 | 114 | 17.9 | 1.00 | 114 | 14.7 | 1.00 | ||||||
| 3-4 | 313 | 8.7 | 2.25 | 1.72 | 2.95 | <.0001 | 312 | 9.2 | 1.76 | 1.34 | 2.31 | .0001 |
| 5-6 | 20 | 4.2 | 5.07 | 2.95 | 8.72 | 20 | 5.8 | 3.08 | 1.79 | 5.32 | ||
| PAI-1 | ||||||||||||
| 0-2 | 192 | 13.3 | 1.00 | 191 | 12.0 | 1.00 | ||||||
| 3-4 | 277 | 7.5 | 1.90 | 1.48 | 2.43 | <.0001 | 277 | 8.1 | 1.61 | 1.23 | 2.09 | .0004 |
| 5-6 | 8 | 4.3 | 3.60 | 2.20 | 5.89 | 8 | 5.5 | 2.58 | 1.52 | 4.38 | ||
1Univariate analyses are unadjusted. Multivariate analyses are adjusted for age, sex, tumor grade, tumor stage, and lymph nodes.
2Median is the median years overall survival as estimated from a parametric model.
3HR is the hazard ratio from a semiparametric (Cox proportional hazards) model. The 95% confidence limits (LCL and UCL) are shown.
4The expression p-values are for trend.