Table 5b. Overall Survival Results for Muscle Invasive Bladder Cancer.

	Univariate Analyses1						Multivariate Analyses1
	n	Median2	HR3	LCL	UCL	p4	n	Median2	HR3	LCL	UCL	p4
Age (years)
≤ 65	176	5.3	1.00				176	5.1	1.00
> 65	248	3.3	1.41	1.12	1.77	.004	248	3.4	1.38	1.10	1.74	.006
Gender
Female	130	2.8	1.00				130	2.7	1.00
Male	297	4.7	0.70	0.55	0.88	.002	294	4.7	0.68	0.54	0.86	.002
Tumor Stage
T2	382	4.1	1.00				381	4.1	1.00
T3 or T4	44	3.7	1.07	0.75	1.52	.73	43	3.5	1.11	0.76	1.60	.59
Lymph Nodes
N0 or NX	312	4.6	1.00				309	4.6	1.00
N1	115	2.7	1.40	1.09	1.81	.008	115	2.7	1.40	1.09	1.80	.009
ANG
0-2	318	4.1	1.00				315	4.0	1.00
3-4	35	2.8	1.26	0.84	1.88	.26	35	3.1	1.20	0.80	1.80	.37
MMP-2
0-2	190	5.5	1.00				189	5.4	1.00
3-4	150	3.2	1.48	1.18	1.86	.0008	148	3.3	1.44	1.14	1.83	.003
5-6	6	1.9	2.19	1.38	3.46		6	2.0	2.08	1.29	3.33
p53
0-2	140	3.2	1.00				140	3.3	1.00
3-4	186	4.2	0.84	0.71	1.00	.05	183	4.2	0.86	0.73	1.02	.09
5-6	59	5.6	0.70	0.50	0.99		59	5.2	0.74	0.53	1.05
Rb
0-2	39	6.5	1.00				38	6.6	1.00
3-4	311	3.7	1.43	1.03	2.00	.03	309	3.7	1.48	1.07	2.03	.02
5-6	11	2.1	2.06	1.06	4.00		11	2.1	2.18	1.15	4.13
PAI-1
0-2	143	5.3	1.00				142	5.0	1.00
3-4	228	3.5	1.37	1.11	1.70	.003	226	3.5	1.30	1.05	1.62	.02
5-6	16	2.3	1.88	1.23	2.88		16	2.5	1.69	1.09	2.62

¹Univariate analyses are unadjusted. Multivariate analyses are adjusted for age, sex, tumor stage, and lymph nodes.

²Median is the median years overall survival as estimated from a parametric model.

³HR is the hazard ratio from a semiparametric (Cox proportional hazards) model. The 95% confidence limits (LCL and UCL) are shown.

⁴The expression p-values are for trend.