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. 2017 Sep 8;8(59):99740–99756. doi: 10.18632/oncotarget.20763

Figure 2. Nlrp3 signaling elimination protects against oxidative and inflammatory effects of the HSD, HFD and HSFD diets.

Figure 2

(A and B) Levels of lipid peroxidation, and protein carbonyls in heart tissues from mice. (C) Protein expression level of 8-oxoguanine glycosylase (OGG-1), MnSOD and catalase. (D-F) Densitometric quantification of protein expression levels of western blots in heart tissues from mice relative to GAPDH (loading control). All data are presented as means ± SEM with a representative blot, n = 6–10 mice. (G and H) IL-1β and TNF-α levels in serum from WT and NLRP3 -/- mice fed with the differents diets were determined by ELISA. All data are presented as means ± SEM with a representative blot, n = 10 mice; *P < 0.05, ***P < 0.001 HSD, HFD and HSFD vs SD; aP < 0.005 WT vs NLRP3 -/-.