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. 2017 Sep 8;8(59):99740–99756. doi: 10.18632/oncotarget.20763

Figure 5. NLRP3 inhibition by MCC950 prevents obesity induced effects of the HSD, HFD and HSFD diets.

Figure 5

(A) Body weight chart of diets-induced obesity in WT-vehicle and MCC950 mice fed with HSD, HFD and HSFD diets. The mice were fed with the diets for 15 weeks and their body weights were monitored weekly. We represent the changes of the final week respect to the first week. (B) Average daily oral food intake normalized to body weight, measured on the different diets. The food intake of mice was measured was monitored weekly. We represent the changes of the final week respect to the first week. (C) Heart weight normalized to body weight. (D-F) Levels of leptin, adiponectin, and ratio in plasma. Blood samples were collected after overnight fasting. All data are presented as means ± SEM, n = 10 mice; *P < 0.05, ***P < 0.005 HSD, HFD and HSFD vs SD; aP < 0.05, aaP < 0.005 MCC950 vs vehicle.