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. 2017 Sep 16;8(59):99816–99824. doi: 10.18632/oncotarget.21071

Figure 1. Three missense mutations of CDC20 identified in patients with IA.

Figure 1

(A) Chromatogram traces from Sanger sequencing showing the validated missense mutations. (B) Evolutionary conservation of amino acids affected by the missense mutations. Multiple protein alignments were performed with MegAlign (Demonstration System DNASTAR, Inc.). The identification numbers of CDC20 protein were as follows: human (NP_001246.2), chimpanzee (NP_001230901.1), rhesus (NP_001248046.1), bovine (NP_001075905.1), rat(NP_741990.1), mouse (NP_075712.2), chicken (NP_001006536.1), xenopus (NP_001079443.1), and zebrafish (NP_998245.2). The mutant alleles are boxed, and the star (*) shows the conserved residue.