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. 2017 Sep 16;8(59):99816–99824. doi: 10.18632/oncotarget.21071

Figure 6. Histogram of four kinds of regulators of relative mRNA expression under dominant-negative effects of CDC20 R383C mutant.

Figure 6

HeLa and 293T cells were transfected with the CDC20 WT or CDC20 R383C mutant with the indicated doses. Levels of mRNA of four genes (PTTG1(securin), CCNB1(cyclin B), CDK1, CDK2) were increased when the cells were transfected with CDC20 R383C mutant compared with transfection of CDC20 WT (*P<0.05). The relative mRNA expression of four genes were detected by Real-Time PCR and compared to GAPDH. WT: wild type, NC: no special control.