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. 2017 Oct 7;8(59):99950–99965. doi: 10.18632/oncotarget.21556

Figure 6. Tumor Growth Inhibition (TGI) after 3C23K administration in ovarian cancer PDXs.

Figure 6

Tumor growth was evaluated by plotting the mean of the RTV (relative tumor volume) ± SEM per group. Between 8 to11 mice per group were included in in vivo experiments. (A) Mice bearing OV16 xenografts were treated either by 3C23K at a dose of 20 mg/kg per injection, twice a week (◊), or by carboplatin at a dose of 66mg/kg and paclitaxel at a dose of 30 mg/kg per injection, every 3 weeks (■), or by carboplatin at a dose of 66mg/kg and paclitaxel at a dose of 66 mg/kg, every 3 weeks, combined with 3C23K at a dose of 20 mg/kg per injection, twice a week (♦). Mice in the control group (○) received 10 ml/kg of the 3C23K-formulating vehicle, PBS, with the same schedule as 3C23K treated animals. (B) Mice bearing OV21 xenografts were treated either by 3C23K (◊), or by carboplatin and paclitaxel (■), or by and paclitaxel at a dose, combined with 3C23K, (♦), as the same schedule as OV16. (C) Mice bearing OV25 xenografts were treated either by 3C23K (◊), or by carboplatin and paclitaxel (■), or by and paclitaxel at a dose, combined with 3C23K, (♦), as the same schedule as OV16. (D) Mice bearing OV42 xenografts were treated either by 3C23K (◊), or by carboplatin and paclitaxel (■), or by and paclitaxel at a dose, combined with 3C23K, (♦), as the same schedule as OV16. (E) Mice bearing OV54 xenografts were treated either by 3C23K (◊), or by carboplatin and paclitaxel (■), or by and paclitaxel at a dose, combined with 3C23K, (♦), as the same schedule as OV16.