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. 2017 Oct 7;8(59):99950–99965. doi: 10.18632/oncotarget.21556

Figure 7. Overall Response Rate (ORR) after 3C23K administration in ovarian cancer PDXs.

Figure 7

The ORR was defined as the relative tumor volume variation (RTVV) of each treated mouse calculated from the following formula: [(Vt/Vc) –1], where Vt is the volume of the treated mouse and Vc the median volume of the corresponding control group at a time corresponding to the end of treatment.(A) ORR of mice treated by 3C23K at a dose of 20 mg/kg per injection, twice a week. (B) ORR of mice treated by carboplatin at a dose of 66mg/kg and paclitaxel at a dose of 30 mg/kg per injection, every 3 weeks. (C) ORR of mice treated by carboplatin at a dose of 66mg/kg and paclitaxel at a dose of 66 mg/kg, every 3 weeks, combined with 3C23K at a dose of 20 mg/kg per injection, twice a week. The two indicated percentages indicate the proportion of mice with a [(Vt/Vc) –1] lower than -0.5 and 0.75, respectively.