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. 2017 Nov 14;10:45–54. doi: 10.1016/j.omtn.2017.11.004

Figure 4.

Figure 4

2′-OMe Modifications in the Gap Region of Hepatotoxic LNA-ASOs Suppress Toxicity In Vitro

Left: schematic illustration of the parent LNA41 and LNA37 ASOs and their 2′-OMe-modified versions LNA41’ and LNA37’ (with two 2′-OMe-modifications in the gap region) and LNA41” and LNA37” (with ten 2′-OMe modifications in the gap region). Right: caspase activity measured 24 hr after transfection of mouse 3T3 fibroblast cells with the indicated LNA-ASOs at 30 nM. Results are shown as a percentage change relative to UTCs. Data (n = 3) are mean ± SD.