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2′-OMe Modifications in the Gap Region of Hepatotoxic LNA-ASOs Suppress Downregulation of Their Intended Target
Myd88 expression was determined 24 hr after transfection of mouse 3T3 fibroblast cells with the indicated LNA-ASOs at 30 nM. Results are shown as a percentage change relative to UTCs. Data (n = 3) are mean ± SD.
