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Effect of the Wing Design on Binding Affinity and LNA-SSO Toxicity
Left: schematic illustration of the parent mGAPDH_LNA1189 and its DNA-substituted wing variants with their respective calculated Tms. Right: caspase activity measured 24 hr after transfection of mouse 3T3 fibroblast cells with the indicated LNA-ASOs at 30 nM. Results are shown as a percentage change relative to UTCs. Data (n = 3) are mean ± SD.
