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. Author manuscript; available in PMC: 2017 Dec 11.

Published in final edited form as: Pharm Res. 2014 May 29;31(10):2796–2809. doi: 10.1007/s11095-014-1377-4

Table V.

Pharmacokinetic Parameters for DIM-P Estimated from Non-Compartment Analysis Following i.v. Administration (5.0 mg/kg Equivalent of DIM-P) in Rats

	DIM-P Solution	NDDs	ENDDs
AUC_0–24 (ug.hr)/ml	124.22 ± 13.65	378.35 ± 95.78	664.17 ± 135.89
K10-HL(hr⁻¹)	2.98 ± 0.65	7.07 ± 0.39	7.56 ± 0.95
Cmax (ug/ml)	216.25 ± 23.59	265.32 ± 29.5	320.26 ± 30.2
Cl (ml/kg/h)	37.74 ± 10.4	12.34 ± 3.69	6.97 ± 1.89
MRT (hr)	2.79 ± 1.02	4.63 ± 1.39	4.65 ± 1.53
Vss (ml/kg)	185.98±29.89	80.93 ± 14.69	49.68 ± 12.98