Table 3.
Multivariable models of outcomes
Competing risk models with death as competing risk | Cox regression | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Outcome | Any event | Stroke | MI | Stroke or MI | Death | |||||
Variable | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value |
Whole sample** | ||||||||||
Age | 1.01 (1.00–1.01) | <0.0001 | 0.99 (0.99–0.99) | <0.0001 | 0.99 (0.98–0.99) | <0.0001 | 0.99 (0.99–0.99) | <0.0001 | 1.06 (1.06–1.06) | <0.0001 |
Female sex† | 0.96 (0.93– 0.99) | 0.004 | 1.05 (0.98–1.12) | 0.2 | 0.88 (0.81–0.95) | 0.001 | 0.98 (0.93–1.03) | 0.4 | 0.95 (0.92–0.99) | 0.01 |
Among those ≥65 yr without adjustment for medications** | ||||||||||
Age | 1.00 (0.99–1.00) | 0.02 | 0.98 (0.98–0.99) | <0.0001 | 0.97 (0.96–0.98) | <0.0001 | 0.98 (0.98–0.98) | <0.0001 | 1.07 (1.06–1.07) | <0.0001 |
Female sex† | 0.94 (0.91–0.97) | 0.0006 | 1.06 (0.98–1.14) | 0.1 | 0.93 (0.84–1.02) | 0.1 | 1.01 (0.95–1.07) | 0.7 | 0.93 (0.90–0.97) | 0.0005 |
Among those ≥65 yr with adjustment for medications@ | ||||||||||
Age | 1.00 (1.00–1.00) | 0.6 | 0.99 (0.98–0.99) | <0.0001 | 0.98 (0.97–0.98) | <0.0001 | 0.98 (0.98–0.99) | <0.0001 | 1.06 (1.06–1.06) | 0.0001 |
Female sex† | 0.94 (0.91–0.97) | 0.0004 | 1.06 (0.98–1.14) | 0.1 | 0.92 (0.84–1.02) | 0.1 | 1.01 (0.95–1.07) | 0.8 | 0.93 (0.89–0.97) | 0.0002 |
MI=myocardial infarction; HTN=hypertension; CAD=coronary artery disease; PVD=peripheral vascular disease;
male sex as referent;
models are adjusted for: income, hypertension, atrial fibrillation, stroke or TIA, MI, CAD, PVD, and Charlson score;
models are adjusted for: income, hypertension, atrial fibrillation, stroke or TIA, MI, CAD, PVD, Charlson score, anti-hypertensive medication use, diabetes medication use, statin use, and warfarin use