Table 2.
Expression of plasma ghrelin, gastric peproghrelin and nociception-related genes in the control and functional dyspepsia groups
| Variables |
Control (n = 87) |
FD (n = 104) |
P value1 |
||||||
| Total | Male | Female | Total | Male | Female | Control vs FD | Control2 | FD2 | |
| (n = 87) | (n = 38) | (n = 49) | (n = 104) | (n = 39) | (n = 65) | ||||
| Plasma acyl ghrelin (fmol/mL, median [IQR]) | 14.1 (9.1-20.8) | 15.9 (9.2-33.7) | 12.2 (9.0-18.6) | 11.2 (6.6-16.8) | 10.4 (6.5-18.4) | 11.4 (6.8-16.5) | 0.018 | 0.204 | 0.388 |
| Plasma des-acyl ghrelin(fmol/mL, median [IQR]) | 67.9 (37.5-162.5) | 108 (31.8-212.9) | 65.4 (38.2-111.0) | 62.1 (32.2-110.6) | 58.5 (28.8-134.3) | 63.6 (32.2-108.0) | 0.297 | 0.389 | 0.913 |
| Ghrelin mRNA (median [IQR]) | 2.6 (0.7-4.9) | 2.1 (0.5-4.2) | 3.2 (1.0-6.1) | 1.7 (0.4-5.4) | 1.9 (0.4-9.0) | 1.5 (0.3-4.7) | 0.435 | 0.076 | 0.308 |
| NGF mRNA (median [IQR]) | 1.1 (0.7-1.7) | 1.2 (0.7-1.8) | 0.9 (0.5-1.6) | 1.6 (0.9-2.3) | 1.8 (1.1-2.7) | 1.4 (0.8-2.2) | 0.006 | 0.056 | 0.129 |
| GDNF mRNA (median [IQR]) | 1.0 (0.7-1.6) | 1.2 (0.8-1.5) | 0.9 (0.7-1.7) | 1.8 (1.0-2.9) | 1.6 (1.1-3.0) | 1.9 (0.9-2.9) | < 0.001 | 0.404 | 0.992 |
| TRPV1 mRNA (median [IQR]) | 1.0 (0.6-1.5) | 1.1 (0.8-1.6) | 0.9 (0.6-1.2) | 1.4 (0.9-2.3) | 1.4 (0.9-2.2) | 1.4 (0.8-2.3) | 0.006 | 0.102 | 0.584 |
1
Mann-Whitney test was used;
2
Male vs female. FD: Functional dyspepsia; GDNF: Glial cell-line derived neurotrophic factor; IQR: Interquartile range; NGF: Nerve growth factor; PDS: Postprandial distress syndrome; TRPV1: Transient receptor potential vanilloid receptor 1.