Table 3.
Expression of plasma ghrelin, gastric peproghrelin and nociception-related genes in different gender
| Variables |
Male |
Female |
||||
| Control (n = 38) | FD (n = 39) | P value1 | Control (n = 49) | FD (n = 65) | P value1 | |
| Plasma acylghrelin (fmol/mL, median [IQR]) | 15.9 (9.2-33.7) | 10.4 (6.5-18.4) | 0.017 | 12.2 (9.0-18.6) | 11.4 (6.8-16.5) | 0.348 |
| Plasma des-acylghrelin (fmol/mL, median [IQR]) | 108.0 (31.8-212.9) | 58.5 (28.9-134.3) | 0.302 | 65.4 (38.2-111.0) | 63.6 (32.2-108.0) | 0.844 |
| Ghrelin mRNA (median [IQR]) | 2.1 (0.5-4.2) | 1.9 (0.4-9.1) | 0.428 | 3.2 (1.0-6.1) | 1.5 (0.3-4.7) | 0.092 |
| NGF mRNA (median [IQR]) | 1.2 (0.7-1.8) | 1.8 (1.1-2.7) | 0.002 | 0.9 (0.5-1.6) | 1.4 (0.8-2.2) | 0.119 |
| GDNF mRNA (median [IQR]) | 1.2 (0.7-1.5) | 1.6 (1.1-3.0) | 0.003 | 0.9 (0.7-1.7) | 1.9 (0.9-2.9) | 0.018 |
| TRPV1 mRNA (median [IQR]) | 1.1 (0.8-1.6) | 1.4 (0.9-2.2) | 0.014 | 0.9 (0.6-1.2) | 1.4 (0.8-2.3) | 0.089 |
1 Mann-Whitney test was used. FD: Functional dyspepsia; GDNF: Glial cell-line derived neurotrophic factor; IQR: Interquartile range; NGF: Nerve growth factor; PDS: Postprandial distress syndrome; TRPV1: Transient receptor potential vanilloid receptor 1.