Table 5. Association between Laboratory Data and Polymorphisms in the ITPKC and SLC11A1 Genes.
Phenotype | SNP | Values | p value |
---|---|---|---|
ITPKC gene | |||
KD vs. control | rs2290692_GC | Elevation of WBC | 0.021 |
rs2290692_GC | Elevation of platelet | 0.024 | |
rs2290692_CC | Elevation of LDH | 0.040 | |
<24 months vs. controls | rs28493229_CC | Elevation of WBC | <0.001 |
rs2290692_GC | Elevation of platelet | 0.046 | |
rs2290692_GC | Elevation of ESR | 0.025 | |
rs10420685_AG | Elevation of LDH | 0.014 | |
≥24 months vs. controls | rs2290692_GC | Elevation of WBC | 0.033 |
rs28493229_CC | Elevation of platelet | 0.008 | |
SLC11A1 gene | |||
<24 months vs. controls | rs2276631_GA | Elevation of AST | 0.022 |
≥24 months vs. controls | rs17235409_GA | Elevation of LDH | 0.050 |
ITPKC, inositol 1,4,5-triphosphate 3-kinase; SLC11A1, solute carrier 11a1; SNPs, single nucleotide polymorphisms; KD, Kawasaki disease; WBC, white blood cell; LDH, lactate dehydrogenase; ESR, erythrocyte sedimentation rate; AST, aspartate aminotransferase