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. 2017 Dec 11;8:2025. doi: 10.1038/s41467-017-01980-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — OFF OS RGC is a distinct functional cell type. a Responses of OFF OS (left) OFF sustained alpha (middle) and OFF transient alpha (right) RGCs to a 1 s flash of 200 μm diameter circular light spot from darkness. Yellow rectangle indicates light stimulus. b Peak firing rate at light offset plotted against mean baseline firing rate for OFF OS (n = 92) and non-OS (n = 84) RGCs. Dotted lines indicate peak firing rate = 135 Hz and mean baseline firing rate = 50 Hz. c Dendritic morphology of two neighbouring OFF OS RGCs. Scale bar = 50 μm. d, e Polar plots of drifting grating responses of OFF OS RGCs coloured in green (d) and (e) orange, respectively. F1 response amplitudes and grating angles are plotted in radial axes and angle axes, respectively. F1 cycle average responses are calculated from three trails in each angle. f Histogram of OSI of OFF OS (n = 92) and non-OS RGCs (n = 84) as identified by their light step response profile. Dotted line indicates OSI = 0.2. g Angle histogram of preferred orientations of OFF OS RGCs recorded in WT retina (black, n = 78) or labelled cells in the JAM-B line (green, n = 14). Dotted line indicates 45° angle