Fig. 5.

Pharmacology of inhibitory conductances in OFF OS RGCs. a, b Effect of gabazine and strychnine on light step responses (200 μm diameter) of example OFF OS RGCs from darkness. Gabazine and strychnine are bath applied first in a, b, respectively. Cells are voltage clamped at E _cat. c Percentage change in peak currents measured at E _cat in inhibitory antagonists a, b. Error bars indicate SEM (n = 4 for gabazine, n = 4 for strychnine and n = 8 for both drugs). d IV relationship for the residual current in both inhibitory antagonists. Inset shows light step response (200 μm diameter) from darkness after application of both inhibitory blockers. Scale for inset: Y-axis = 100 pA, X-axis = 200 ms. Error bars indicate SEM across n = 8 cells