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. 2017 Dec 7;11:662. doi: 10.3389/fnins.2017.00662

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Copyright © 2017 Beltz and Benton.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Testing serotonin as a link between the nervous and immune systems. Our working model describing serotonin's role in adult neurogenesis includes stimulating the expression of AST1, which in turn promotes the release of semi-granular hemocytes and accelerates the rate of adult neurogenesis. These relationships will be further tested using agents that enhance or suppress serotonin's action (e.g., quizapine maleate salt [QMS] and PCPA, respectively). While the influence of these compounds on adult neurogenesis in crayfish is known, it has not yet been determined if these effects are mediated by AST1, or result from direct influences of serotonin.