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. 2017 Dec 11;8:2035. doi: 10.1038/s41467-017-02185-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — RanBP6 suppresses growth factor output and glioma growth. a Focal deletions of the RANBP6 (left) and CDKN2A (right) loci in GBM. b Relationship between RANBP6 copy number and mRNA levels in GBM (n = 151); Tukey’s honest significant difference: ***p < 0.001. c RanBP6 protein levels in a panel of established patient-derived GBM tumor spheres. The immunoblots of whole-cell lysates are shown. d Ectopic expression of RanBP6-V5 in RanBP6-low TS516 GBM neurosphere reduces anchorage-independent growth. e Ectopic expression of RanBP6-V5 reduces EGFR protein levels in a time-dependent manner. f RanBP6 overexpression reduces tumor growth (left panel) and EGFR expression in a TS516 xenograft model (right panel). Student’s t test: *p < 0.05. g RanBP6 KD reduces survival in RCAS-tva mouse glioma model. Kaplan–Meier survival curves of PDGFB-induced gliomas generated in Nestin-tva mice injected with either RCAS-RanBP6 shRNA or RCAS-Luciferase shRNA as a control. h Tumor grade (WHO classification) of gliomas in the RCAS-tva model. i RanBP6 KD increases Egfr mRNA in samples from the RCAS-tva mice. Data in bar graphs are represented as mean ± SD (n ≥ 3)