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. 2017 Dec 11;7:17344. doi: 10.1038/s41598-017-17337-7

Table 1.

Pathway terms ranked by methods (left) and LRM. *is for cancer specific terms.

DESeq LRM
*ECM-Receptor Interaction Collagen Formation, Assembly of Collagen Fibrils, Collagen Biosynthesis Cytokine-Cytokine Receptor Interaction *Cell Adhesion Molecules ( CAMs ) *PI3K-Akt Signaling Pathway Protein Digestion and Absorption *Cancer Specific Terms (FDR-corrected P-value)
Cell Adhesion Molecules (6.53E-10)ECM-Receptor Interaction (5.68E-06)Focal Adhesion (1.54E-05)PI3K-Akt Signaling Pathway (2.52E-03)p53 Signaling Pathway (9.31E-03)ECM Organization (3.41E-02)
NOISeq Top Scored Terms (FDR-corrected P-value)
* ECM-Receptor Interaction Collagen formation, Assembly of Collagen Fibrils, Collagen Biosynthesis, Protein Digestion and Absorption *Cell adhesion molecules ( CAMs )Leishmaniasis, Interferon Gamma Signaling Phagosome (7.42E-12)Complement System (8.09E-11)Protein Digestion and Absorption (6.53E-10)Leishmaniasis (3.59-08)Collagen Formation (1.26E-08)Allograft Rejection (1.24E-07)Viral myocarditis (1.55E-07)Graft-versus-host disease (1.75E-07)Type I diabetes mellitus (3.19-07)Asthma (1.45E-07)Rheumatoid Arthritis (6.46E-06)Cell Cycle (5.68E-06)Autoimmune thyroid disease (4.02E-05)IgA Intestinal Immune Network Production (1.31E-05)Tuberculosis (4.31E-05)Hematopoietic cell lineage (2.02E-04)Pertussis (2.12E-04)Systemic Lupus Erythematosus (2.60E-04)HTLV-I infection (2.88E-03)Spinal Cord Injury (1.19E-03)Inflammatory Bowel Disease (IBD) (2.16E-03)Toxoplasmosis (5.02E-03)Natural killer cell mediated cytotoxicity (6.95E-03)Insulin Processing (2.43E-03)Leukocyte transendothelial migration (1.27E-02)
CuffDiff
*ECM-Receptor Interaction Immunoregulatory Interactions between a Lymphoid and a non-Lymphoid cell *Cell adhesion molecules ( CAMs )Collagen formation, Hemostasis Assembly of Collagen Fibrils Natural killer Cell Mediated Cytotoxicity *Rap1 signaling pathway
Limma
*ECM-Receptor Interaction Hemostasis, Complement and Coagulation Cascades, Collagen formation, Cyclin B2 Mediated Events, Cytokine-Cytokine Receptor Interaction, Collagen Biosynthesis
GeneSpring
Cell Cycle, Mitotic Prometaphase, Mitotic Metaphase and Anaphase, Separation of Sister Chromatids, Mitotic Anaphase, Resolution of Sister Chromatid Cohesion
PCA
Rheumatoid Arthritis, Phosphorylation CD3 and TCR, Hematopoietic Cell Lineage, TCR Signaling, ZAP-70 Translocation, Cytokine-cytokine receptor interaction *PD-1 signaling