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. 2017 Dec 11;7:17355. doi: 10.1038/s41598-017-17729-9

Figure 2.

Figure 2

Radiomitigation is TLR2 and MyD88 specific. Male C57BL/6 mice were administered physiological water (NT), 0.25 mg/kg FSL–1, 0.25 mg/kg Pam2CSK4 or 0.25 mg/kg Pam3CSK4 at 24 hours after 9.2 Gy TBI exposure. (a) Survival was recorded through 30 days post TBI. Data is cumulative of 2 independent experiments with n = 4–6 mice per group per experiment. (b) Clinical score and (c) percent body weight change were assessed in comparison to irradiated, non–treated controls (TBI, NT). C57BL/6 or MyD88 −/− male and female mice were administered physiological water (NT) or 0.25 mg/kg FSL–1 at 24 hours post 9.2 Gy TBI. (d) Survival, (e) clinical score, and (f) percent body weight change were assessed for 30 days post TBI. Data is representative of 2 experiments with n = 6 to 10 as indicated in legend. Data are shown as mean ± s.e.m. *P < 0.05, **P < 0.01, ***P < 0.001 or ****P < 0.0001 between treated and TBI, NT mice, with colors correlating to treatment group.