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. 2017 Dec 11;7:17324. doi: 10.1038/s41598-017-17652-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Graphical representation of generation of resistant breast cancer cells from sensitive breast cancer cells. Docetaxel sensitive MDA-MB-231 and MDA-MB-468 cells were cultured and treated with low dose of docetaxel and then dose was increased gradually to generate resistant breast cancer cells. (B and C) Phase contrast images of sensitive and resistant breast cancer cells. Scale bar represents 100 µm. (D and E) Actin organization of sensitive and resistant breast cancer cells was shown in figure. Sensitive cells were small in size, normal actin organization. The actin organization of resistant cells was elongated and parallel orientation of actin filaments. (F and G) Akt expression in sensitive and resistant breast cancer cells (Blots were cropped and presented). The significance level was represented by *P < 0.05, **P < 0.01, ***P < 0.001.