Fig. 1.

(A) Model-estimated median titer of shed type 2 poliovirus as a function of neutralizing antibody titers pre-mOPV2 challenge and nominal day post-challenge of stool sample collection. Lines indicate regression fit to observed data ignoring censoring at NAb LLOQ (2.5 log₂) and ULOQ (10.5 log₂). Observed data points are jittered to convey density. Samples negative for viral shedding are assigned a value of 0. (B) The same as panel A, except data (circles) are not jittered, and values at NAb LLOQ/ULOQ are replaced with one illustrative realization form the censored-data simulation (triangles). Median regression line indicates model fit predictions aggregated across censored data simulations.