Table 2.

Levels of different bile acids in plasma of cognitively healthy subjects, MCI patients and patients suffering from Alzheimer´s disease

Analyte	DL	Control (n = 30)	MCI (n = 20)	AD (n = 30)	CO versus MCI	CO versus AD	MCI versus AD
CA, cholic acid	10	215 ± 51	155 ± 43	224 ± 161	ns	ns	ns
CDCA, chenodeoxycholic acid	6	361 ± 84	284 ± 61	1245 ± 1009	ns	ns	ns
DCA, deoxycholic acid	6	455 ± 68	291 ± 50	723 ± 236	ns	ns	ns
GCA, glycocholic acid	10	423 ± 145	207 ± 24	332 ± 51	ns	ns	ns
GCDCA, glycochenodeoxycholic acid	6	1326 ± 223	1156 ± 105	1951 ± 301	ns	p = 0.06	p = 0.035
GDCA, glycodeoxycholic acid	3	640 ± 90	504 ± 105	956 ± 180	ns	p = 0.09	p = 0.034
GLCA, glycolithocholic acid	3	41 ± 8	27 ± 4	66 ± 15	ns	ns	p = 0.026
GUDCA, glycoursodeoxycholic acid	3	160 ± 29	137 ± 17	137 ± 24	ns	ns	ns
LCA, lithocholic acid	3	32 ± 3	41 ± 4	50 ± 6	ns	p = 0.004	ns
TCA, taurocholic acid	6	134 ± 64	40 ± 9	99 ± 25	ns	ns	ns
TCDCA, taurochenodeoxycholic acid	3	211 ± 58	170 ± 37	347 ± 71	ns	ns	ns
TDCA, taurodeoxycholic acid	3	97 ± 23	72 ± 20	152 ± 36	ns	ns	ns
TLCA, taurolithocholic acid	3	8 ± 2	5 ± 1	11 ± 2	ns	ns	ns
TMCA(a + b), tauromuricholic acid (sum)	3	15 ± 3	17 ± 5	24 ± 5	ns	ns	ns
TUDCA, tauroursodeoxycholic acid	3	8 ± 1	8 ± 1	11 ± 2	ns	ns	ns
UDCA, ursodeoxycholic acid	6	88 ± 23	62 ± 17	209 ± 149	ns	ns	ns
Sum of all bile acids		4214 ± 419	3176 ± 324	6537 ± 1163	ns	p = 0.031	ns

Values represent nM in mean ± SEM. Statistical analysis was performed by One Way ANOVA with a subsequent Fisher LSD posthoc test where p < 0.05 was considered as significant

DL detection limit, ns not significant