Table 6.
Experimental
Potential % |
Predicted
Potential % |
Predicted
Potential % |
||||
---|---|---|---|---|---|---|
Linear (MLR) | Non-linear (SVM) | |||||
Series I. Magnolol Analogues | ||||||
R1 | R2 | R3 | ||||
1 | H | pentyl | H | 5 | 4.4 | 0.9 |
2 | H | hexyl | H | 7 | 6.1 | 5.1 |
3 | methyl | butyl | H | 5 | 4.8 | 3.5 |
4 | methyl | pentyl | H | 3 | 3.5 | 2.6 |
5 | methyl | hexyl | H | 7 | 6.4 | 7.0 |
6 | ethyl | propyl | H | 5 | 4.4 | 5.0 |
7 | ethyl | butyl | H | 3 | 4.6 | 3.0 |
8 | ethyl | pentyl | H | 3 | 3.1 | 3.0 |
9 | propyl | pentyl | H | 5 | 5.3 | 3.9 |
10 | propyl | hexyl | H | 5 | 2.7 | 4.8 |
11 | propyl | heptyl | H | 1 | 1.1 | 3.2 |
12 | propyl | octyl | H | 1 | -0.3 | 1.0 |
13 | butyl | pentyl | H | 5 | 6.2 | 3.9 |
14 | butyl | hexyl | H | 3 | 2.5 | 3.0 |
15 | ethyl | pentyl | CH3 | 7 | 7.5 | 6.6 |
16 | ethyl | hexyl | CH3 | 5 | 5.0 | 5.0 |
17 | propyl | pentyl | CH3 | 1 | 3.3 | 3.0 |
18 | propyl | hexyl | CH3 | 1 | 0.5 | 1.0 |
19 | pentyl | ethyl | CH3 | 3 | 2.6 | 3.6 |
20 | pentyl | propyl | CH3 | 3 | 3.5 | 3.0 |
21 | hexyl | propyl | CH3 | 1 | -0.1 | 0.8 |
Series II. 4’-O-methyl Honokiol Analogues | ||||||
1 | methyl | methyl | - | 1 | 1.1 | 1.0 |
2 | ethyl | methyl | - | 3 | 2.8 | 3.0 |
3 | propyl | methyl | - | 10 | 9.2 | 10.0 |
4 | butyl | methyl | - | 10 | 8.9 | 10.0 |
5 | pentyl | methyl | - | 7 | 8.2 | 7.0 |
6 | hexyl | methyl | - | 10 | 8.5 | 9.6 |
7 | heptyl | methyl | - | 7 | 6.4 | 7.1 |
8 | octyl | methyl | - | 1 | 3.1 | 3.2 |
9 | hexyl | ethyl | - | 3 | 4.5 | 3.3 |
10 | hexyl | propyl | - | 1 | 2.6 | 1.0 |
11 | hexyl | isopropyl | - | 1 | 0.5 | 1.0 |