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. 2017 Dec 11;7:17295. doi: 10.1038/s41598-017-17543-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Axial MRI images of one rat in series 1: before Gd injection T2w (A), T1w (B) and T1 FLASH (C), T1w (D) and T1 FLASH after Gd injection (E). Substantial damage is observed. A large lesion with a high signal in T2w along with low signal in T1w and no BBB, compatible with an edema, is present in the left hippocampus. Several areas of chronic haemorrhage in the corpus callosum, subiculum and hippocampi presenting a rim of low intensity and a centre of high signal in T2w with an isotense signal in T1w and high intensity in T1w FLASH are observed. Some areas of bleeds are also present with low intensity both in T2w and T1w. An extensive BBB breakdown is also observed.