Fig. 5.

Estimation accuracy of T cell subsets within the T cell population and clinically relevant ratios of T cells and their dependence on the origin and quality of RGEPs. a Scatter plot of true and estimated cell proportions for all 27 patient samples. Each dot represents one patient sample. Values close to the diagonal correspond to high deconvolution accuracy. Columns depict cell types; rows describe the five different configurations (REGP1-3 and CNTR1-2). ρ denotes the Pearson’s correlation coefficient. In configuration REGP1, estimates for tumour-associated cell types are not available. b Pearson’s correlation coefficient between estimated and true cell fraction for all five configurations. Dots denote the median of the correlation coefficient; the shading represents the uncertainty based on bootstrapping (upper and lower quartile). (Please note the different scaling of the figure axes.)