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. 2017 Dec 12;37(6):BSR20171038. doi: 10.1042/BSR20171038

Figure 4. miR-6743-5p regulates the activity of STAT3 via GRIM-19.

Figure 4

U251 cells were treated as described in Figure 3. (A) Protein levels of GRIM-19, p-STAT3, and STAT3 were assessed by Western blot analyses at 48 h after indicated treatment. GAPDH was detected as loading control. (B) The mRNA levels of CyclinD1 and Bcl-2 were detected by real-time PCR analysis at 48 h post treatment. ***P<0.001 compared with Mock and anti-miR-control + shNC; #P<0.05 compared with anti-miR-6743-5p + shNC; +++P<0.001 compared with anti-miR-control + shGRIM-19.