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. 2018 Jan 10;28(2):131–140. doi: 10.1089/ars.2017.7106

FIG. 2.

FIG. 2.

In vitro cell survival assay at various oxygen levels. (A) Cell survival assay assessed after 2 h of treatment of varying concentrations of TH-302 under aerobic (150 mmHg oxygen) or anoxic (0 mmHg oxygen) conditions on SCCVII and HT29 cells. (B) Cell survival assay on SCCVII cells assessed after 2 h of treatment of varying concentrations of TH-302 at various oxygen levels. (C) The effect of oxygen levels on toxicity of TH-302 (HCR) and signal intensity as measured by EPR spin-trapping studies shown in Figure 1D and E. TH-302 HCR was determined from three experiments; error bars represent the SE. HCR, hypoxic cytotoxicity ratio; SE, standard error.