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In vivo tumor growth assay. (A, B) Tumor growth assessed by doubling time in size after five times of treatment with TH-302 and/or XRT (3 Gy) on SCCVII tumor-bearing C3H/HeN mice (A) and HT29 tumor-bearing athymic nude mice (B). (C, D) Kaplan–Meier plot of SCCVII/C3H (C) and HT29/nude mice (D). Mice were sacrificed when the tumor volume reached 2000 mm3. Data are mean ± SE of five (A, C) or five to seven (B, D) mice. *p < 0.05, **p < 0.001. XRT, radiotherapy.
