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. 2017 Sep 26;106(1):168–179. doi: 10.1002/jbm.a.36223

Figure 1.

Figure 1

Calcium chelation ability of AA and VPA. In PAA, Calcium binds to the carboxylate groups from neighboring polymer segments. In PVPA, VPA performs as a monoprotic acid and it is the close proximity of the phosphonate groups, coupled with the strong negative charge of ions, which chelate the calcium ions.