Table 1.
Clinical studies of co-infusion of MSCs with HSCs for hematopoietic recovery after hematopoietic stem/progenitor cell transplantation
| Number of patients | Median age of patients, years (range) | HSC donor | MSC donor | MSC dose (×106/kg) | Median time for Neut recovery (range) | Median time for Plt recovery (range) | Reference |
|---|---|---|---|---|---|---|---|
| 46 | 44.5 (19–61) | HLA-matched sibling | HSC donor | 1.0, 2.5, or 5.0 | Neut >500/μl at day 14 (11–26) | Plt >20,000/μl at day 20 (15–36) | [26] |
| 7 | 12 (1–44) | HLA-matched sibling in three cases Unrelated donor in three cases Cord blood in one case |
HLA-matched sibling or HLA-haploidentical donor | 1.0 | Neut >500/μl at day 12 (10–28) | Plt >30,000/μl at day 12 (8–36) | [27] |
| 8 | 7.5 (0.25–16) | Cord blood | HLA-haploidentical parent | 0.9–5.0 | Neut >500/μl at day 19 (9–28) | Plt >50,000/μl at day 53 (36–98) | [28] |
HLA human leukocyte antigen, HSC hematopoietic stem/progenitor cell, MSC mesenchymal stromal/stem cell, Neut neutrophil, Plt platelet